Bağımlılık bir beyin hastalığıdır. Yani bağımlılık yapıcı maddeler uzun süre boyunca kullanıldığında beyin hücrelerinde farklı etkilere ve değişimlere yol açarlar. Beynimizin ön kısmında bizlere “Dur ya da Git” mesajlarını veren bir merkez vardır. Bu merkez yapmak istediğimiz şeyler için bize “Git” mesajını verirken, yapmamamız gereken ya da yapmak istemediğimiz durumlar için “Dur” mesajını verir. Bağımlı olan kişilerin beyninde ise “Dur” mesajını veren kısım yeterince iyi aktif olmamaya başlar. “Dur” diyen kısım sessizleştikçe; “Git” diyen kısım sesini yükseltir. Bunların sonucunda kişinin karar verme yetisinde bozulmalar olur, risk alma davranışları artar, davranışlarının sonuçlarını düşünmemeye başlar ve kişi düşünmeden hareket eder.
Kişinin düşünceleri ve duyguları üzerindeki kontrolü azalmaya başlar. Bağımlı kişi ‘bir kereden bir şey olmaz’, “istediğim zaman bırakabilirim’ gibi kontrolün kendisinde olduğuna dair oluşan düşünce tuzaklarına düşerler.
Günlük hayatta farklı durumlarda (yemek yemek, cinsel yaşam, başarı elde etmek vb.) salgılanan dopamine bağımlılık yapıcı maddeler doğrudan ya da dolaylı şekilde uyarıcı etki yaparlar. Bazıları dopamin salınımını doğrudan uyarırken bazıları endorfin salınımına sebep olarak dopamin salınımını arttırmada dolaylı etkiye sahiptirler. Bağımlılık yapıcı maddeler doğal yolla salgılanan dopamine kıyasla daha ani, daha şiddetli ve buna bağlı olarak daha fazla haz verici olur. Bağımlı kişilerin duygu yoğunluğunda artış gerçekleşir. Suçluluk, karamsarlık ve pişmanlık gibi duygular yoğun bir şekilde hissedilmeye başlanır. Aynı zamanda günlük işlere odaklanmada güçlük, yakın zamanda gerçekleşen olayları hatırlamada zorluk gibi dikkat ve hafıza süreçleri de etkilenmeye başlar.
Bağımlılığın sosyal, psikolojik, biyolojik, genetik ve davranışsal sebeplerden kaynaklandığı bilinir. Ancak bağımlılığın nedenini tek bir koşul ile açıklamak mümkün değildir. Çok büyük ihtimalle tek bir nedenden dolayı değil birden fazla nedenin birleşmesi ile bağımlılık ortaya çıkmaktadır. Kişi maddeyi arttırıyorsa, maddeyi almadığında yoksunluk belirtileri (kramplar, depresyon) yaşıyorsa ve madde alımı ile bu belirtiler ortadan kalkıyorsa, sosyal, ruhsal, bedensel zararlar yaşıyorsa, sorumluluklarını ihmal ediyorsa madde bağımlılığı seçeneğinin değerlendirilmesi gerekir. Bağımlılık tedavi edilebilir bir hastalıktır. Özellikle tedavide kullanılan ilkeleri yerine getiren kişilerin maddeyi bırakma oranı oldukça yüksektir. Kişinin bağımlılık süreci ile baş etmesi çok zor olsa da, o kişiyi tedaviye yönlendirmek yapılabilecek en iyi seçenektir.
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